Promogran Prisma Matrix Wound Dressing
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3M Promogran Prisma Matrix — Only ORC + Collagen + Silver, 3.4x More Wound Closures, 2 Sizes
The only collagen dressing in the world with Oxidized Regenerated Cellulose (ORC) — proven in a meta-analysis to give wounds 3.4 times greater odds of closure than standard dressings. 3M Promogran Prisma Matrix is a sterile freeze-dried composite of 55% collagen, 44% ORC, and 1% silver-ORC — three components working together in a way no other collagen dressing can replicate. When applied to the wound bed, Promogran Prisma transforms on contact with exudate into a soft, conformable, biodegradable gel that covers and adapts to the entire wound surface — no gaps, no dead space. The ORC component is the clinical differentiator: ORC absorbs and inactivates the matrix metalloproteinases (MMPs) and elastases that are chronically elevated in stalled wounds, removing the primary biochemical barrier to healing that standard moisture-management dressings cannot address. The collagen provides native scaffolding for cell proliferation, fibroblast migration, and granulation tissue formation. The ionically bound silver-ORC delivers an effective antibacterial barrier against common wound pathogens. The biodegradable gel absorbs progressively into the wound — no painful removal required. Backed by randomized controlled trials and meta-analysis, the Promogran Matrix Family are the only collagen dressings with this evidence base.
✔ Only Collagen Dressing With ORC — Unique Worldwide, Not Available in Any Other Collagen Dressing ✔ 3.4x Greater Odds of Wound Closure — Proven in Meta-Analysis of 10 RCTs ✔ ORC Inactivates MMPs — Removes the Biochemical Barrier That Stalls Chronic Wounds ✔ Biodegradable Gel — No Removal Required, Absorbs Into the Wound ✔ Ionically Bound Silver — Antibacterial Barrier Against Common Wound Pathogens
Product Details
| Manufacturer | Solventum (Formerly 3M / Systagenix / KCI) |
|---|---|
| Product | Promogran Prisma Matrix — Collagen/ORC/Silver Wound Dressing |
| Available Sizes | 2 sizes — MA028 (4.34 sq in) and MA019 (19.1 sq in) — see size guide below |
| Composition | 55% Collagen, 44% Oxidized Regenerated Cellulose (ORC), 1% Silver-ORC (25% w/w ionically bound silver — 0.017 mg/sq cm total silver) |
| ORC Technology | Only collagen dressing with ORC — absorbs and inactivates MMPs and elastases that chronically stall wound healing |
| Clinical Evidence | Meta-analysis of 10 RCTs — 3.4x greater odds of wound closure vs standard dressings (OR=3.4, 95% CI [1.15, 10.1], p=0.027) |
| Silver | Ionically bound silver-ORC — antibacterial barrier against Pseudomonas aeruginosa, Staph aureus, E. coli, and Strep pyogenes in vitro |
| Gel Formation | Transforms into soft conformable biodegradable gel on contact with exudate — covers all wound areas including contours |
| Biodegradable | Yes — gel absorbs progressively into the wound, no painful removal required |
| Change Frequency | Every 72 hours or as directed — residual dressing does not need to be removed at change |
| Compression Compatible | Yes — suitable for use under compression bandaging |
| NPWT Compatible | Yes — compatible with 3M ActiV.A.C. Therapy System (note: when slit for NPWT use, bacterial barrier not maintained) |
| MRI Safety | MRI Unsafe — do not use on patients during MRI examination |
| Secondary Dressing | Required — semi-occlusive or non-occlusive secondary dressing to maintain moist environment |
| Sterility | Sterile — 10 per box (MA028) | 5 per box (MA019) |
| HCPCS Codes | A6021 (MA028 — 4.34 sq in) | A6022 (MA019 — 19.1 sq in) |
Indicated For — Wound Types
- Diabetic foot ulcers — stalled or chronic
- Venous leg ulcers — with or without compression
- Pressure injuries and ulcers — all stages
- Ulcers caused by mixed vascular etiologies
- Traumatic wounds — abrasions, lacerations, donor sites
- Surgical wounds — post-operative and dehisced wounds healing by secondary intention
- Full and partial thickness wounds with exudate
- Wounds stalled in the inflammatory phase — where standard dressings have failed to progress healing
- Arterial ulcers
- Post-Mohs surgery and post-laser surgery wounds
Contraindications: Not indicated for third-degree burns, wounds with necrotic tissue, or patients with known sensitivity to silver, ORC, or collagen. May be used on infected wounds only when proper medical treatment is addressing the underlying infection. Not a substitute for infection treatment. MRI Unsafe — remove before MRI examination.
How It Works — ORC + Collagen + Silver, Three Actions Together
Chronic wounds stall because of a specific biochemical problem — elevated matrix metalloproteinases (MMPs) degrade the collagen matrix faster than the wound can rebuild it, and chronically high elastase levels break down growth factors before they can stimulate cell migration and proliferation. Standard wound dressings manage moisture and exudate but do nothing to address this biochemical imbalance — which is why many chronic wounds simply don't progress despite optimal wound care. Promogran Prisma Matrix is the only dressing specifically formulated to correct this imbalance. The ORC component acts as a direct MMP trap — absorbing and inactivating MMPs and elastases from wound fluid, removing the biochemical barrier to healing at its source. With MMPs neutralized, the collagen scaffold can persist and function — providing the structural framework for fibroblast and keratinocyte migration across the wound bed, supporting granulation tissue formation, and creating the 3-D architecture for new tissue growth. The ionically bound silver-ORC provides an effective antibacterial barrier simultaneously — so the improved wound environment created by MMP reduction is protected from bacterial disruption. The entire composite transforms into a soft biodegradable gel that conforms to the wound surface, and this gel is progressively absorbed into the wound — requiring no removal at dressing changes, eliminating one of the most painful and disruptive aspects of collagen dressing management.
- ORC absorbs and inactivates MMPs and elastases — removes the biochemical barrier that stalls chronic wound healing
- Only collagen dressing with ORC — this mechanism is not available in any other collagen wound dressing
- Collagen scaffold supports fibroblast migration, granulation tissue formation, and epithelialization
- Ionically bound silver-ORC — antibacterial barrier against common wound pathogens in vitro
- Transforms into biodegradable conformable gel — covers all wound contours, including tunnels and undercuts
- Gel absorbs into wound over time — no removal required at dressing changes
- Maintains physiologically moist microenvironment — supports all phases of wound healing continuously
- Proven in meta-analysis of 10 RCTs — 3.4x greater odds of wound closure vs standard dressings
- Can kick-start wounds stalled in the inflammatory phase — the primary clinical use case
- Compression and NPWT compatible — versatile across wound management protocols
What Makes ORC Different — Why No Other Collagen Dressing Does This
| Component | What It Does | Why It Matters |
|---|---|---|
| ORC (44%) | Absorbs and inactivates MMPs and elastases from wound fluid — bioresorbable, degrades through gel formation | Removes the primary biochemical barrier to healing in stalled chronic wounds — only ORC does this |
| Collagen (55%) | Provides 3-D scaffold for fibroblast migration, cell proliferation, granulation tissue and epithelialization | Structural support for new tissue growth — works effectively once MMPs are controlled by ORC |
| Silver-ORC (1%) | Ionically bound silver released at wound surface — antibacterial barrier against common wound pathogens | Protects the improved healing environment from bacterial disruption while ORC and collagen work |
How to Apply — Step by Step
| Step | Action |
|---|---|
| 1 | Prepare wound bed per standard protocol — debride necrotic tissue before applying (Promogran Prisma is not indicated for necrotic wounds) |
| 2 | Cut to fit the wound with scissors if needed — cover the entire wound bed |
| 3 | If wound has exudate — apply directly to the wound bed, exudate will initiate gel transformation |
| 4 | If wound is dry — moisten dressing with sterile saline or Ringer's solution before or after application to initiate gel formation |
| 5 | Cover with a semi-occlusive or non-occlusive secondary dressing fixed with non-irritating tape |
| 6 | At dressing change — residual gel does not need to be removed, apply fresh Promogran Prisma directly over wound every 72 hours |
Choosing the Right Size
- MA028 — 4.34 sq in (approx. 2¼" x 2¼" hexagon) — 10/box — Standard size — the most widely used size for general diabetic ulcer, venous ulcer, and pressure injury management. The hexagon shape provides better wound edge coverage than a standard square. Best for wounds up to approximately 4 square inches in surface area.
- MA019 — 19.1 sq in (approx. 4¾" x 4¾") — 5/box — Large size — for broader wounds, large pressure injuries, extensive post-surgical sites, and any wound that exceeds the coverage area of the standard MA028. Can be cut to shape. More cost-effective per square inch for large wound applications.
Storage: Store below 25°C (77°F) away from direct light. Some discoloration from light exposure may occur but does not affect silver release or clinical performance.
Not sure which size is right for your wound? Call 1-866-218-0902 — Mon–Fri, 9am–5pm EST
Why Buy From Medical Department Store?
- 30+ years serving home medical, wound care, and clinical supply customers
- 110% Low Price Guarantee — we beat any competitor's price
- Medical supply specialists on the phone — not a call center
- Ships to all 50 states — 5 Southwest Florida locations for local pickup
- Full-service medical supply store — Home Medical Equipment, Mobility, Respiratory & Beds
Questions about Promogran Prisma Matrix or any of our collagen wound care products? Call 1-866-218-0902 — our team is ready to help.
