Human BioSciences Medifil II Collagen Particles
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Human BioSciences Medifil II Collagen Particles — 100% Native Bovine Collagen, All 4 Healing Phases, 1g Vials
The only collagen particle dressing with proprietary Kollagen technology — delivering more intact native collagen to the wound surface than any standard collagen dressing. Medifil II Collagen Particles by Human BioSciences are a 100% non-hydrolyzed type I bovine native collagen wound dressing in particle form — a format that maximizes the surface area of collagen contact with the wound bed, allowing the maximum concentration of bioactive collagen molecules to interact with the wound microenvironment simultaneously. The proprietary Kollagen technology process used to manufacture Medifil II preserves significantly more of the native triple-helical protein structure of the collagen molecule than standard hydrolyzed collagen dressings — and this structural integrity is clinically critical. It is the triple-helical form of collagen that provides scaffolding for cell migration, stimulates fibroblast and keratinocyte proliferation, absorbs matrix metalloproteinases (MMPs) that degrade healing tissue, and supports all four phases of wound healing from hemostasis through remodeling. Delivered in easy-pour 1g single-use vials — apply directly to the wound bed, mix with saline for tunneling wounds, and cover with a secondary dressing.
✔ 100% Non-Hydrolyzed Native Type I Bovine Collagen — Intact Triple-Helical Structure ✔ Proprietary Kollagen Technology — Retains More Native Protein Structure Than Standard Collagen ✔ Particle Format — Maximum Surface Area, Maximum Collagen-to-Wound Contact ✔ Supports All 4 Phases of Wound Healing — Hemostasis Through Remodeling ✔ Mix With Saline for Tunneling & Cavity Wounds — Versatile Application
Product Details
| Manufacturer | Human BioSciences, Inc. (HBS) |
|---|---|
| Item Number | MF2001 |
| Format | Particles — 1g single-use easy-pour vials, 5 vials per box |
| Collagen Type | 100% non-hydrolyzed type I bovine native collagen — intact triple-helical molecular form |
| Kollagen Technology | Proprietary manufacturing process — retains significantly more native triple-helical protein structure than standard hydrolyzed collagen dressings |
| BSE Source | Bovine collagen sourced from certified negligible BSE risk region — World Organization for Animal Health designated |
| Application Depth | Apply to ¼" depth across entire wound bed surface |
| Tunneling Use | Mix with normal saline to create paste — draw into syringe and apply to tunneled or undermined areas |
| Change Frequency | Minimally draining — every 2–3 days | Moderately draining — when saturated | Infected wounds — daily until infection resolved |
| Compatibility | Compatible with topical medications and all standard secondary dressings — gauze, foam, transparent film, hydrocolloid, superabsorbent |
| Secondary Dressing | Required — cover with absorbent secondary dressing appropriate to exudate level |
| Shelf Life | 5 years |
| Sterility | Sterile — single-use vials, sterile until opened |
| HCPCS Code | A6010 |
Indicated For — Wound Types
- Partial and full thickness wounds
- Pressure ulcers — all stages
- Venous ulcers — chronic and acute
- Diabetic ulcers and neuropathic wounds
- Chronic vascular ulcers
- Tunneled and undermined wounds — mix with saline for cavity application via syringe
- Surgical wounds — donor sites, grafts, post-Mohs surgery, post-laser surgery, podiatric wounds, wound dehiscence
- Trauma wounds — abrasions, lacerations, second degree burns, and skin tears
- Draining wounds requiring collagen scaffolding and exudate absorption
- Any chronic or acute wound where collagen supplementation supports wound bed preparation and healing
Contraindications: Do not use on third-degree (full thickness) burns. Do not use in patients with known bovine collagen sensitivity. Extremely dry wounds may not be appropriate — consider HBS Collatek Collagen Gel for dry wound applications. Each vial is intended for single use only — sterile until opened.
How Medifil II Works — Why Particle Form and Native Structure Matter
Most collagen wound dressings are manufactured from hydrolyzed collagen — a process that breaks the collagen molecule into smaller peptide fragments to make it more soluble and easier to process into sheets or gels. The problem with hydrolysis is that it destroys the triple-helical structure of the collagen molecule — the precise geometric form that gives collagen its biological activity in wound healing. Hydrolyzed collagen retains some beneficial properties but loses the structural scaffolding capability, the MMP-absorbing capacity, and the cell-signaling properties of intact native collagen. Medifil II is manufactured using Human BioSciences' proprietary Kollagen technology specifically to preserve this triple-helical structure — delivering intact, bioactive native type I collagen to the wound bed rather than collagen fragments. The particle format maximizes the exposure of this native collagen to the wound microenvironment — the small particle size creates an extremely high surface area per gram of collagen, ensuring more collagen molecules are in direct contact with wound fluid, cells, and tissue simultaneously than any equivalent-weight sheet or gel dressing can achieve.
- Intact triple-helical structure — provides active scaffolding for fibroblast and keratinocyte migration across the wound bed
- Absorbs matrix metalloproteinases (MMPs) — MMPs degrade healing tissue in chronic wounds, collagen acts as a sacrificial substrate to protect it
- Stimulates healing across all four phases — hemostasis, inflammation, proliferation, and remodeling
- Particle format — maximum surface area per gram, maximum collagen-to-wound contact
- Reduces inflammation — collagen interaction with the wound microenvironment modulates inflammatory mediators
- Removes exudate — particles absorb wound fluid and its harmful components
- Retains more native protein structure than hydrolyzed collagen — Kollagen technology process protects molecular integrity
- Compatible with topical medications — can be combined with prescribed topicals before secondary dressing application
- Mixable with normal saline — creates injectable paste for syringe delivery into tunneling and undermined wound areas
- 5-year shelf life — exceptional stability for stocking in clinical and home care settings
The Four Phases of Wound Healing — How Collagen Supports Each
| Phase | How Medifil II Native Collagen Supports This Phase |
|---|---|
| 1 — Hemostasis | Collagen activates platelets and supports clot formation — native triple-helical collagen is a potent platelet activator |
| 2 — Inflammation | Collagen absorbs MMPs and modulates inflammatory mediators — helps transition the wound from the inflammatory to proliferative phase |
| 3 — Proliferation | Triple-helical scaffolding supports fibroblast migration, granulation tissue formation, and angiogenesis across the wound bed |
| 4 — Remodeling | Native collagen supports organized tissue remodeling and tensile strength restoration — structural integrity of the healed wound |
How to Apply — Step by Step
| Step | Action |
|---|---|
| 1 | Cleanse wound per physician order — preferably with normal saline or non-cytotoxic wound cleanser |
| 2 | Do NOT dry the wound — leave moist for best result with Medifil II particles |
| 3 | Apply topical medication to wound bed if prescribed — then apply ointment or cream to wound margin if desired |
| 4 | Pour Medifil II particles to ¼" depth across entire wound bed — for tunneling wounds mix with saline to form paste, draw into syringe, and apply to tunnel |
| 5 | Cover with appropriate absorbent secondary dressing — gauze, foam, superabsorbent, transparent film, or hydrocolloid |
| 6 | At dressing change — irrigate wound with saline until particles loosen and lift gently away |
Why Buy From Medical Department Store?
- 30+ years serving home medical, wound care, and clinical supply customers
- 110% Low Price Guarantee — we beat any competitor's price
- Medical supply specialists on the phone — not a call center
- Ships to all 50 states — 5 Southwest Florida locations for local pickup
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Questions about Medifil II or any of our collagen wound care products? Call 1-866-218-0902 — our team is ready to help.
